PROTAC
mode of action
mode of action
PROTAC protein degraders offer critical advantages over traditional small molecules and genetic-based crop solutions.
| PROTAC protein degrader distinct advantages | PROTAC protein degraders | Small molecule inhibitors | Gene-based solutions |
|---|---|---|---|
| Eliminate undesirable proteins |  Yes |
Yes |
|
| Target scaffolding function | Yes |
Yes |
|
| Potential to target “undruggable” proteins | Yes |
Yes |
|
| Iterative mechanism of action | Yes |
||
| Combats resistance | Yes |
Yes |
|
| Flexible timing of application (sprayer) | Yes |
Yes |
|
| No modifications to genome | Yes |
Yes |
In healthcare, researchers are using PROTAC protein degraders to fight aggressive, complex diseases like prostate cancer. This emerging platform toolset harnesses and modulates proteins to precisely impact natural pathways—delivering immediate, therapeutic effects while underlying genes are left undisturbed.
What if we can use this powerful, therapeutic path across the entire food system?
Oerth Bio’s PROTAC platform will allow farmers to unlock and direct this natural process within plants, tailoring applications to better suit each plant’s needs in a changing world.
Our proprietary PROTAC® platform
The plant ubiquitin proteasome pathway plays a central role in plant environment interaction, mediated by E3 ligases. There are over 1,400 predicted E3 ubiquitin ligases in plants, at least 2 times more than in human systems. Oerth Bio’s PROTAC platform will allow farmers access to unlock and direct this natural process within plants, tailoring applications to better suit each crop’s needs in a changing world.
Oerth Bio™ is a multidisciplinary agtech company with a target-based approach to discovery. The solutions we design have the power to fundamentally enhance the resilience, durability, and quality of our global food supply—while minimizing agriculture’s environmental footprint.
Our approach to discovery
Novel
targets
Digital
discovery
Plant e3
“degradome”
Delivery
technology
targets
Novel targets
Interrogate traditionally “undruggable” targets. Work with partners to identify acute food system unmet needs.
discovery
Digital discovery
Proactively design compounds using breakthroughs in DNA sequencing, bioinformatics, artificial intelligence, and computational chemistry.
“degradome”
Plant E3 “degradome”
Increase designed molecule safety profiles via an unsurpassed understanding of the natural ubiquitin ligase complex found in plants.
technology
Delivery technology
Focus on delivery and formulation innovation to maximize plant performance and minimize off-target effects for humans, bees, and the environment.