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PROTAC protein degraders offer critical advantages over traditional small molecules and genetic-based crop solutions.

PROTAC protein degrader distinct advantages PROTAC protein degraders Small molecule inhibitors Gene-based solutions
Eliminate undesirable proteins Yes Yes
Target scaffolding function Yes Yes
Potential to target “undruggable” proteins Yes Yes
Iterative mechanism of action Yes
Combats resistance Yes Yes
Flexible timing of application (sprayer) Yes Yes
No modifications to genome Yes Yes

In healthcare, researchers are using PROTAC protein degraders to fight aggressive, complex diseases like prostate cancer. This emerging platform toolset harnesses and modulates proteins to precisely impact natural pathways—delivering immediate, therapeutic effects while underlying genes are left undisturbed.

What if we can use this powerful, therapeutic path across the entire food system?

Oerth Bio’s PROTAC platform will allow farmers to unlock and direct this natural process within plants, tailoring applications to better suit each plant’s needs in a changing world.

Our proprietary PROTAC® platform

The plant ubiquitin proteasome pathway plays a central role in plant environment interaction, mediated by E3 ligases. There are over 1,400 predicted E3 ubiquitin ligases in plants, at least 2 times more than in human systems. Oerth Bio’s PROTAC platform will allow farmers access to unlock and direct this natural process within plants, tailoring applications to better suit each crop’s needs in a changing world.

Oerth Bio™ is a multidisciplinary agtech company with a target-based approach to discovery. The solutions we design have the power to fundamentally enhance the resilience, durability, and quality of our global food supply—while minimizing agriculture’s environmental footprint.

Our approach to discovery

PROTAC
mode of action
Novel
targets
Digital
discovery
Plant e3
“degradome”
Delivery
technology