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3rd annual Ligase Targeting Drug Development conference

Hijacking E3 Ligases to Mediate Degradation & Modulation of Undrugged Targets

As a family of over 600 known proteins, ligases pose immense potential as viable avenues for harnessing previously undrugged targets. Key challenges remain however to rapidly discover and identify novel and underexploited ubiquitin E3s. Furthermore, bottlenecks exist in development of the established ligases; Cereblon and VHL.

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