Attune integrates three key pillars of the protein modulation process for developing a precise, tunable, agricultural solution.
Ligase selection, binder discovery
- Rationally designed ligands
- Computational modeling
- DEL screens
- Ligase <> target pairing
- Species specificity
- Structural biology
Rapid PROTAC Molecule Design
- Proprietary E3 ligase library
- Plants, fungi and insect targets
- "Zone of Ubiquitination"
- Oearth bioavailability "Rules"
Agricultural use case validation
- Biochemical characterization
- In-cell performance
- Whole organism validation
- Greenhouse and field evaluation
- Selectivity / safety assessments