Delivering the benefit of biological solutions without the downsides
Oerth's PROTAC platform delivers the reliability and strengths of traditional synthetic small molecules, with the precision of gene editing, all with a naturally mediated mode of action.
PROTAC molecules comprise three separate regions (a protein-binding domain, an E3 ligase binding domain, and a linker). Each element of a PROTAC molecule provides opportunities for high precision product development.
Lower application rates
Unlike other approaches that operate with a one-to-one ratio (one molecule per one target site), PROTAC molecules work catalytically, recycling within the cell. This could significantly decrease application rates, saving farmers both time and money.
Expanded target landscape
PROTAC molecules have the potential to overcome biological resistance issues plaguing existing approaches. They also open an expanse of new targets previously considered too challenging, or unreachable by conventional methods. PROTAC molecules also overcome issues faced by other natural solutions, like the need for special storage and temperature.
Ease of use
Understanding that farmers routinely work with conventional agrochemicals and equipment, PROTAC molecules can be formulated for use with conventional equipment and facilities. They are amenable to tank mixing, and can be stored in challenging barn conditions such as heat and cold temperatures. This makes it a sustainable plug-and-play option for farmers.
PROTAC molecules are manufactured via known, predictable, and optimized chemistry pathways.